Therapeutic proteins are the engineered proteins in the laboratory intended for pharmaceutical use. The first therapeutic protein was Insulin, used for treating Diabetes in the 1920’s. Under definite conditions, recombinant DNA technology makes it easy to produce proteins in particular host cells such as bacteria, yeast, or mammalian cells. The host for production is chosen on the basis of the protein required. Mammalian cells are the most preferred host cell as their posttranslational modifications like glycosylation and sialylation have the biggest impact on the protein’s pharmacokinetics and protein’s efficiency.
Therapeutic proteins aid in the personalized medicine concept as they make it easy for the individualized treatment by associating with the specifically targeted therapeutic procedure by recompensing the deficiency of the deficient protein. Antibodies are the fastest growing class of therapeutic proteins. The Antibodies support the immune response; furthermore, they can even induce accumulation of therapeutic agents at a tumor site by conjugation or fusion.
Global Therapeutic Protein Market: Dynamics
Latest innovations in Recombinant Proteins have changed the scenario, and the increase in antibody-based drugs have headed to research on engineering protein scaffolds. According to NCBI, the latest advances in protein engineering technologies have allowed drug developers and manufacturers to fine-tune and exploit desirable functional characteristics of proteins of interest while maintaining (and in some cases enhancing) product safety or efficacy or both. New engineered proteins, including bispecific mAbs and multispecific fusion proteins, mAbs conjugated with small molecule drugs, and proteins with optimized pharmacokinetics, are currently under development.
However, in the last several decades, there are no conceptually new methodological developments comparable, e.g., to genetic engineering leading to the development of recombinant therapeutic proteins. It appears that a paradigm change in methodologies and understanding of mechanisms is needed to overcome major challenges, including resistance to therapy, access to targets, the complexity of biological systems, and individual variations.
Some of the significant trends in the therapeutic proteins market are hepatic metabolism and the rapid elimination, are a major setback to the clinical applications of therapeutic proteins, thus increasing the focus on Biobetters. Obstacles in production, Protein solubility, distribution, stability, delivery route (blood or alimentary may degrade it), physiologically active-post translational modifications and cost are the biggest challenges in the therapeutic protein market.
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Global Therapeutic Protein Market: Segmentation
By Indications, the Global Therapeutic Protein market can be segmented into,
- Infectious Diseases
- Multiple Sclerosis
- Hepatitis B/C
By Therapeutic Protein, the Global Therapeutic Protein market can be segmented into,
- Monoclonal Antibodies
- Human Growth Hormone
- Follicle Stimulating Hormone
- Blood Clotting Factors
- Granulocyte-colony stimulating factor
- Colony Stimulating Factor
- Enzyme Replacement proteins
- Bone morphogenetic proteins
- Fc fusion proteins
- engineered protein scaffolds
By End User, the Global Therapeutic Protein market can be segmented into,
- Pharmaceutical companies
- Healthcare service providers
- Research Organizations
- Academic Research Institutes
By Region, the Global Therapeutic Protein market can be segmented into,
- North America
- Asia Pacific
- Latin America
- Middle East & Africa
Global Therapeutic Protein Market: Region-wise Outlook
Geographically, North America is the dominating region in the Therapeutic Protein market owing to the greater research and development work on therapeutic proteins going on in the North America and Europe. Rising awareness of Therapeutic Proteins amongst the individuals and healthcare professionals has fueled the Therapeutic Protein market. Asia Pacific and Latin America are the most lucrative markets, and both these regions most likely will exhibit a strong CAGR during the forecast years. The growth in this region is attributed to the increase in funding for research and development and entry of established players in these regions.
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Global Therapeutic Protein Market: Key Players
Currently, the global Therapeutic Protein market is highly competitive owing to the involvement of many established players. Some of the key players in the Global Therapeutic Protein are Amgen Inc, Abbott Laboratories, AstraZeneca, Baxter International, Boehringer Ingelheim, Chugai Pharmaceutical, Diasome Pharmaceuticals, Eli Lilly & Company, F. Hoffmann-La Roche, Generex Biotechnology, Genentech, GeneScience Pharmaceuticals, Group Biogen Idec Inc, Hualan Biological Engineering, Johnson & Johnson, Kyowa Hakko Kirin, Merck Serono S.A, Novo Nordisk, Oramed Pharmaceuticals, ProBiogen AG, Sandoz International, Teva Pharmaceutical Industries and many more.