The plasminogen activator inhibitor is of two types that is plasminogen activator inhibitor type 1 (PAI-1) and plasminogen activator inhibitor type 2 (PAI-2). They are the members of a superfamily of serpins or serine protease inhibitors. The deficiency of plasminogen activator inhibitor type 1 (PAI-1) results in abnormal bleeding. The bleeding patterns of plasminogen activator inhibitor deficiency have been reported in many types, like delayed surgical bleeding, joint and intracranial bleeding after mild trauma and severe menstrual bleeding. The PAI-1 deficiency can be life-threatening and plays a key role in large numbers of age-related disorders such as inflammation, insulin resistance, atherosclerosis, obesity, Werner syndrome comorbidities etc. Whereas PAI-2 deficiency has not been observed in humans or other mammals, it is secreted by the placenta during pregnancy insignificant amount helps in early embryonic development or placental maintenance. Apart from that, the PAL-1 is found as a major factor for fibrinolysis. However, no such diagnostic criteria have been established yet for the diagnosis of plasminogen activator inhibitor. But, certain drugs are being prescribed by the physicians to control and manage to bleed such as antifibrinolytics, tranexamic acid and epsilon-aminocaproic acid (EACA). The incidence of complete plasminogen activator inhibitor type 1 deficiency is found as higher in the genetic isolate of the old order Amish population of eastern and southern Indiana of U.S. Complete plasminogen activator inhibitor type-1 deficiency is genetically inherited equally by both sexes. However, it should be diagnosed earlier and more frequently in females because of its effects on childbirth, menstruation and pregnancy.
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The plasminogen activator inhibitor market can be segmented by plasminogen activator inhibitor type, product types and end-users.
Based on the plasminogen activator inhibitor type the plasminogen activator inhibitor market can be segmented as
Based on the drug types the plasminogen activator inhibitor market can be segmented as
- Tranexamic Acid
- Epsilon-Aminocaproic Acid (EACA)
Based on the end-users the plasminogen activator inhibitor market can be segmented as
- Home Care Settings
The abnormal bleeding due to the deficiency of plasminogen activator inhibitor drives the growth of the plasminogen activator inhibitor market. Increasing prevalence of age-related disorders all over the world drives the plasminogen activator inhibitor market. The wide use of medications such as ibuprofen, aspirin etc. that affect coagulation can propel the growth of the plasminogen activator inhibitor market. However, increasing recall of products such as PAL kits is affecting the growth of the plasminogen activator inhibitor market. For instance, the U.S. Food and Drug Administration recalled IMUBIND Plasma PAI-1 Enzyme-Linked Immunosorbent Assay (ELISA) kits manufactured by American Diagnostica, Inc. in July 2016.
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The deficiency of plasminogen activator inhibitor is life-threatening and results in abnormal bleeding. Due to its adverse effect on pregnancy, mensuration and childbirth, the plasminogen activator inhibitor should be earlier diagnosed and frequently treated in case of female. Consequently, the market of plasminogen activator inhibitor is expected to be higher during forecast periods. However, due to the unavailability of FDA approved drugs and specific diagnosis procedure the plasminogen activator inhibitor market is providing opportunities to the major key players for new product manufacture in near forecasting periods.
The U.S is expected to share a large market of plasminogen activator inhibitor due to the growing research activities on age-related disorders and pregnancy complications and increasing focus on routine health checkup followed by Europe. Considerable market growth of plasminogen activator inhibitor has also been expected from the Middle East, Asia Pacific and African countries due to the increasing awareness of pregnancy-related disorders. Prominent growth of plasminogen activator inhibitor market has been expected from the emerging countries such as China, India, Brazil and South Africa in the forecast years which will provide a huge opportunity to lunch new product among the market players.
Some of the key players operating in the plasminogen activator inhibitor market are, Bayer AG, Pfizer Inc., SteadyMed, GlaxoSmithKline, Merck & Co Inc., Abcam Plc among others.
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